Supplement Scholar
Peptide

TB-500 (Thymosin Beta-4)

Prescription drug or research compound. Use only under the care of a licensed prescriber. Information here is educational and not a recommendation to obtain or use it.

TB-500 (Thymosin Beta-4). Synthetic thymosin β-4 fragment researched for tissue repair; not approved.

How it works. Promotes actin polymerization, cell migration, and angiogenesis.

What the research supports. 1 graded claims. Strongest: Animal repair data; no robust human evidence (limited).

How much to take. Typical dose: Investigational.

Side effects and interactions. 1 medication interaction listed. Serious: Unregulated; WADA-banned.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA). Avoid combining with Athletes (banned).

Common forms. Available as Injectable.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried TB-500 (Thymosin Beta-4). Anecdotes are not medical advice.

TB-500 (Thymosin Beta-4). Synthetic thymosin β-4 fragment researched for tissue repair; not approved.

Molecular structureC38H68N10O14 · 889.0 g/mol

What it is

Synthetic thymosin β-4 fragment researched for tissue repair; not approved.

Food sources

Synthetic peptide

Goals

Recovery OptimizationJoint & Connective Tissue

How it works

Promotes actin polymerization, cell migration, and angiogenesis.

Pathways

  • Actin polymerization
  • Angiogenesis

Effects

  • +Tissue repair (animal) supports

What the research supports

Animal repair data; no robust human evidencelimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
Investigational
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the injectable form.

Side effects & interactions

Serious

  • Unregulated; WADA-banned

Medication interactions

Prescription medications (general)minor

Always disclose TB-500 (Thymosin Beta-4) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Avoid combining

  • Athletes (banned)WADA Prohibited List.

Common forms

  • Injectable

Key studies

8 studies cited in total.

PubMed: TB-500 (Thymosin Beta-4) — Animal repair data; no robust human evidence ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "Animal repair data; no robust human evidence". Filter by RCT, meta-analysis, or year on the results page.

PubMed: TB-500 (Thymosin Beta-4) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: TB-500 (Thymosin Beta-4) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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