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Mineral

Strontium Ranelate (Ref)

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Strontium Ranelate (Ref). Reference strontium salt used as anti-osteoporotic drug.

How it works. Promotes osteoblastogenesis and inhibits osteoclast activity.

What the research supports. 1 graded claims. Strongest: Reduces vertebral fracture risk (strong).

How much to take. Typical dose: Rx 2 g/day.

Side effects and interactions. 1 medication interaction listed. Serious: Increased CV risk.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Chelated form (glycinate, bisglycinate, citrate, malate), Inorganic salt (oxide, sulfate, chloride), Liquid ionic solution, Topical or transdermal preparation.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Strontium Ranelate (Ref). Anecdotes are not medical advice.

Strontium Ranelate (Ref). Reference strontium salt used as anti-osteoporotic drug.

Molecular structureC12H6N2O8SSr2 · 513.5 g/mol

What it is

Reference strontium salt used as anti-osteoporotic drug.

Food sources

Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)Fortified foods such as cereals, breads, plant milks, and table saltMineral supplements as chelates, citrates, glycinates, or inorganic salts

Goals

Bone Health

How it works

Promotes osteoblastogenesis and inhibits osteoclast activity.

Pathways

  • Promotes osteoblastogenesis
  • inhibits osteoclast activity

Effects

  • ↓vertebral fracture risk decreases

What the research supports

Reduces vertebral fracture riskstrong

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
Rx 2 g/day
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the chelated form (glycinate, bisglycinate, citrate, malate) form.
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Side effects & interactions

Common side effects

  • Diarrhea

Serious

  • Increased CV risk

Medication interactions

Prescription medications (general)minor

Always disclose Strontium Ranelate (Ref) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Chelated form (glycinate, bisglycinate, citrate, malate)
  • Inorganic salt (oxide, sulfate, chloride)
  • Liquid ionic solution
  • Topical or transdermal preparation

Key studies

8 studies cited in total.

PubMed: Strontium Ranelate (Ref) — Reduces vertebral fracture risk ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Strontium Ranelate (Ref) and "Reduces vertebral fracture risk". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Strontium Ranelate (Ref) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Strontium Ranelate (Ref) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Strontium Ranelate (Ref) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Strontium Ranelate (Ref) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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