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Mineral

Strontium Citrate

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Strontium Citrate. Mineral that substitutes for calcium in bone — controversial but increases BMD measurements.

How it works. Replaces Ca²⁺ in hydroxyapatite, stimulating osteoblasts and inhibiting osteoclasts.

What the research supports. 1 graded claims. Strongest: Increases BMD (strontium ranelate Rx — CV risk) (moderate).

How much to take. Typical dose: 340–680 mg elemental Sr (citrate form).

Side effects and interactions. 1 medication interaction listed. Serious: CV/VTE risk (ranelate Rx).

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Chelated form (glycinate, bisglycinate, citrate, malate), Inorganic salt (oxide, sulfate, chloride), Liquid ionic solution, Topical or transdermal preparation.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Strontium Citrate. Anecdotes are not medical advice.

Strontium Citrate. Mineral that substitutes for calcium in bone — controversial but increases BMD measurements.

Molecular structureC6H5O7Sr- · 276.72 g/mol

What it is

Mineral that substitutes for calcium in bone — controversial but increases BMD measurements.

Food sources

Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)Fortified foods such as cereals, breads, plant milks, and table saltMineral supplements as chelates, citrates, glycinates, or inorganic salts

Goals

Bone DensityOsteoporosis PreventionBone Health

How it works

Replaces Ca²⁺ in hydroxyapatite, stimulating osteoblasts and inhibiting osteoclasts.

Pathways

  • Replaces Ca²⁺ in hydroxyapatite, stimulating osteoblasts
  • inhibiting osteoclasts

Effects

  • ↑BMD (strontium ranelate Rx — CV risk) increases

What the research supports

Increases BMD (strontium ranelate Rx — CV risk)moderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
340–680 mg elemental Sr (citrate form)
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEmpty stomach away from calcium
Best formMost evidence is based on the chelated form (glycinate, bisglycinate, citrate, malate) form.
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Side effects & interactions

Serious

  • CV/VTE risk (ranelate Rx)

Medication interactions

Calcium supplementsmoderate

Compete for absorption — separate by 2h.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Chelated form (glycinate, bisglycinate, citrate, malate)
  • Inorganic salt (oxide, sulfate, chloride)
  • Liquid ionic solution
  • Topical or transdermal preparation

Key studies

8 studies cited in total.

PubMed: Strontium Citrate — Increases BMD ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Strontium Citrate and "Increases BMD". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Strontium Citrate — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Strontium Citrate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Strontium Citrate — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Strontium Citrate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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