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Silymarin (Liver Dose)

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Silymarin (Liver Dose). Standardized silybin-rich extract for liver disease.

How it works. Antioxidant, anti-fibrotic and membrane-stabilizing on hepatocytes.

What the research supports. 1 graded claims. Strongest: Lowers ALT in NAFLD (moderate).

How much to take. Typical dose: 420 mg silymarin/day.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Milk thistle (silymarin), NAC.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Silymarin (Liver Dose). Anecdotes are not medical advice.

Silymarin (Liver Dose). Standardized silybin-rich extract for liver disease.

Key compound: silybinC25H22O10 · 482.4 g/mol

What it is

Standardized silybin-rich extract for liver disease.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Liver Health

How it works

Antioxidant, anti-fibrotic and membrane-stabilizing on hepatocytes.

Pathways

  • Antioxidant, anti-fibrotic
  • membrane-stabilizing on hepatocytes

Effects

  • ↓ALT in NAFLD decreases

What the research supports

Lowers ALT in NAFLDmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
420 mg silymarin/day
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith meals
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Silymarin (Liver Dose) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Silymarin (Liver Dose) — Lowers ALT in NAFLD ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Silymarin (Liver Dose) and "Lowers ALT in NAFLD". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Silymarin (Liver Dose) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Silymarin (Liver Dose) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Silymarin (Liver Dose) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Silymarin (Liver Dose) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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