SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Herb

Saffron (Eye)

Crocin-rich saffron studied for AMD and visual function.

Eye Health

Overview

Crocin-rich saffron studied for AMD and visual function.

Natural sources
    Common forms

      Forms & variants of Saffron

      Different chemical forms of Saffron behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Saffron

      Culinary spice with antidepressant effects comparable to SSRIs in mild-moderate depression.

      Parent
      Saffron (Crocus sativus)

      Crocin-rich spice with antidepressant effects comparable to SSRIs in mild–moderate depression.

      Mechanism of action

      Crocin protects retinal photoreceptors from oxidative stress.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves ERG function in early AMD

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Safety & non-supplemental interactions

              Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

              Avoid if you are
              • ·Pregnant or breastfeeding (insufficient safety data)
              • ·Children under 18 (unless directed by a clinician)

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              20 mg saffron
              With food?
              Either

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Herb
              Saffron (Eye)
              Amazon
              Wide selection · fast shipping
              Herb
              Saffron (Eye)
              iHerb
              Global delivery · curated brands
              Herb
              Saffron (Eye)
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTInvest Ophthalmol Vis Sci · 2010

              Saffron in early AMD

              Falsini B, et al.

              3-month DB-RCT in 25 AMD patients.

              Key findings

              Improved retinal flicker sensitivity vs placebo.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Saffron (Eye) — Improves ERG function in early AMD

              Live PubMed search

              Live results for "Saffron (Eye) Improves ERG function in early AMD" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Saffron (Eye) and "Improves ERG function in early AMD". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Saffron (Eye) — randomized controlled trial

              Live PubMed search

              Live results for "Saffron (Eye) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Saffron (Eye) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Saffron (Eye) — meta-analysis

              Live PubMed search

              Live results for "Saffron (Eye) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Saffron (Eye) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Saffron (Eye) — pharmacokinetics

              Live PubMed search

              Live results for "Saffron (Eye) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Saffron (Eye) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Saffron (Eye) — safety adverse events

              Live PubMed search

              Live results for "Saffron (Eye) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Saffron (Eye) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Saffron (Eye) — dose response

              Live PubMed search

              Live results for "Saffron (Eye) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Saffron (Eye) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Saffron (Eye) — clinical evidence

              Live Scholar search

              Cross-database citation index for Saffron (Eye) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.