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evidence · mechanism · dose
Supplements/Compound

Rapamycin (Rx, reference)

mTOR inhibitor — most validated geroprotector in animal models; not a supplement.

Longevity PathwaysHealthy Aging (alias)Biological Age

Overview

mTOR inhibitor — most validated geroprotector in animal models; not a supplement.

Natural sources
    Common forms

      Mechanism of action

      Selectively inhibits mTORC1, mimicking caloric restriction signaling.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Extends median/maximal lifespan in mice across strains

        Strong evidence

        Human longevity unproven

        Limited evidence

        Potential side effects

        Common
        • · Mouth sores
        • · Glucose intolerance
        Rare
        • · Immunosuppression
        Serious
        • · Infection risk

        Drug interactions

        Most CYP3A4 substrates
        Major interaction risk.
        severe

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        Off-label longevity protocols: 5–6 mg weekly (Rx, MD supervision)
        With food?
        Empty stomach

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
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        Amazon
        Wide selection · fast shipping
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        iHerb
        Global delivery · curated brands
        Compound
        Rapamycin (R…
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (9)

        Systematic reviewGeroscience · 2021

        Rapamycin and mammalian aging: state of the field

        Selvarani R, et al.

        Review of rapamycin's anti-aging evidence.

        Key findings

        Robust life-extension in mice across genetic backgrounds.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Rapamycin (Rx, reference) — Extends median/maximal lifespan in mice across strains

        Live PubMed search

        Live results for "Rapamycin (Rx, reference) Extends median/maximal lifespan in mice across strains" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "Extends median/maximal lifespan in mice across strains". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Rapamycin (Rx, reference) — Human longevity unproven

        Live PubMed search

        Live results for "Rapamycin (Rx, reference) Human longevity unproven" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "Human longevity unproven". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Rapamycin (Rx, reference) — randomized controlled trial

        Live PubMed search

        Live results for "Rapamycin (Rx, reference) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Rapamycin (Rx, reference) — meta-analysis

        Live PubMed search

        Live results for "Rapamycin (Rx, reference) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Rapamycin (Rx, reference) — pharmacokinetics

        Live PubMed search

        Live results for "Rapamycin (Rx, reference) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Rapamycin (Rx, reference) — safety adverse events

        Live PubMed search

        Live results for "Rapamycin (Rx, reference) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Rapamycin (Rx, reference) — dose response

        Live PubMed search

        Live results for "Rapamycin (Rx, reference) dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Rapamycin (Rx, reference) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Rapamycin (Rx, reference) — clinical evidence

        Live Scholar search

        Cross-database citation index for Rapamycin (Rx, reference) as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.