Overview
mTOR inhibitor — most validated geroprotector in animal models; not a supplement.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Selectively inhibits mTORC1, mimicking caloric restriction signaling.
- · Selectively inhibits mTORC1, mimicking caloric restriction signaling
Effects on the body
Organ system effects
Evidence-based benefits
Extends median/maximal lifespan in mice across strains
Strong evidenceHuman longevity unproven
Limited evidencePotential side effects
- · Mouth sores
- · Glucose intolerance
- · Immunosuppression
- · Infection risk
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Rapamycin (Rx, reference) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Rapamycin (Rx, reference) third party tested NSF
CapsulesPre-measured Rapamycin (Rx, reference) capsules — easiest for travel and consistent daily dosing without scoops or scales.Rapamycin (Rx, reference) capsules
PowderBulk unflavored Rapamycin (Rx, reference) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Rapamycin (Rx, reference) powder unflavored
Best sellersMost-purchased Rapamycin (Rx, reference) products on Amazon — a quick way to see what's reviewed widely before you commit.Rapamycin (Rx, reference) best sellerScientific evidence9Show studiesHide studies
Rapamycin and mammalian aging: state of the field
Selvarani R, et al.
Review of rapamycin's anti-aging evidence.
Robust life-extension in mice across genetic backgrounds.
PubMed: Rapamycin (Rx, reference) — Extends median/maximal lifespan in mice across strains
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PubMed: Rapamycin (Rx, reference) — Human longevity unproven
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PubMed: Rapamycin (Rx, reference) — randomized controlled trial
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PubMed: Rapamycin (Rx, reference) — dose response
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Google Scholar: Rapamycin (Rx, reference) — clinical evidence
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Cross-database citation index for Rapamycin (Rx, reference) as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.