Phenibut (caution)
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Phenibut (caution). GABA-B agonist with high abuse and dependence potential; restricted in many countries.
How it works. GABA-B receptor agonist (like baclofen).
What the research supports. 1 graded claims. Strongest: Anxiolytic short-term (limited).
How much to take. Typical dose: Not recommended; if used: ≤500 mg, max 2×/week.
Side effects and interactions. 1 medication interaction listed. Serious: Severe withdrawal syndrome.
Stacking. Pairs well with Magnesium glycinate, L-theanine. Avoid combining with Regular use, Alcohol.
Forms. 1 forms. Pick one to open its profile.
Key studies. 8 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Phenibut (caution). Anecdotes are not medical advice.
Phenibut (caution). GABA-B agonist with high abuse and dependence potential; restricted in many countries.
What it is
GABA-B agonist with high abuse and dependence potential; restricted in many countries.
Food sources
Goals
How it works
GABA-B receptor agonist (like baclofen).
Pathways
- GABA-B agonism
Effects
- ↓Anxiety (short term) decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Drowsiness
Serious
- Severe withdrawal syndrome
- Dependence
- Overdose with alcohol
Medication interactions
Severe additive sedation / respiratory depression.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- Magnesium glycinateComplementary GABAergic calming and improved sleep architecture.
- L-theanineReduces sleep latency without sedation.
Avoid combining
- Regular useSevere withdrawal and dependence.
- AlcoholLife-threatening interaction.
Forms
Key studies
8 studies cited in total.
Opens current human and preclinical literature matching Phenibut (caution) and "Anxiolytic short-term". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Phenibut (caution) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Phenibut (caution) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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