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Vitamin

Niacinamide

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Niacinamide. Non-flushing B3 — used for deficiency, skin health, and at high doses in dermatology.

How it works. Direct NAD+ precursor (does not affect lipids like niacin).

What the research supports. 2 graded claims. Strongest: Reduces non-melanoma skin cancer recurrence (moderate).

How much to take. Typical dose: 16 mg RDA; 500 mg BID for skin cancer prevention.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Collagen peptides, Vitamin C.

Common forms. Available as Capsule or softgel, Sublingual tablet or liquid, Methylated active form for sensitive individuals, Multivitamin matrix.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Niacinamide. Anecdotes are not medical advice.

Niacinamide. Non-flushing B3 — used for deficiency, skin health, and at high doses in dermatology.

Molecular structureC6H6N2O · 122.12 g/mol

What it is

Non-flushing B3 — used for deficiency, skin health, and at high doses in dermatology.

Food sources

Whole-food sources (animal products for fat-soluble and B-complex vitamins; produce for water-soluble vitamins)Fortified foods (cereals, dairy, plant milks, nutritional yeast)Multivitamins or stand-alone supplements in synthetic or food-derived form

Goals

Skin, Hair & NailsGeneral Wellness

How it works

Direct NAD+ precursor (does not affect lipids like niacin).

Pathways

  • Direct NAD+ precursor (does not affect lipids like niacin)

Effects

  • ↓non-melanoma skin cancer recurrence decreases
  • +rosacea/acne supports

What the research supports

Reduces non-melanoma skin cancer recurrencemoderate
Improves rosacea/acnelimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
16 mg RDA; 500 mg BID for skin cancer prevention
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodOptional
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Medication interactions

Prescription medications (general)minor

Always disclose Niacinamide use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
  • Vitamin CRequired cofactor for collagen hydroxylation.

Common forms

  • Capsule or softgel
  • Sublingual tablet or liquid
  • Methylated active form for sensitive individuals
  • Multivitamin matrix

Key studies

9 studies cited in total.

PubMed: Niacinamide — Reduces non-melanoma skin cancer recurrence ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Niacinamide and "Reduces non-melanoma skin cancer recurrence". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Niacinamide — Improves rosacea/acne ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Niacinamide and "Improves rosacea/acne". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Niacinamide — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Niacinamide and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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