Supplement Scholar
Mushroom

Lion's Mane Erinacines

Buy on Amazon ↗

Affiliate link: we may earn a commission at no extra cost to you. Disclosures

Lion's Mane Erinacines. Hericium erinaceus mycelium for NGF.

How it works. Erinacines stimulate NGF synthesis.

What the research supports. 1 graded claims. Strongest: May improve mild cognitive impairment (moderate).

How much to take. Typical dose: 1000 mg mycelium.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Omega-3 (EPA/DHA), Alpha-GPC or CDP-choline.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Lion's Mane Erinacines. Anecdotes are not medical advice.

Lion's Mane Erinacines. Hericium erinaceus mycelium for NGF.

Key compound: erinacine AC25H36O6 · 432.5 g/mol

What it is

Hericium erinaceus mycelium for NGF.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Brain & Cognitive

How it works

Erinacines stimulate NGF synthesis.

Pathways

  • Erinacines stimulate NGF synthesis

Effects

  • +May improve mild cognitive impairment supports

What the research supports

May improve mild cognitive impairmentmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
1000 mg mycelium
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the capsule or softgel form.
Shop Lion's Mane Erinacines on Amazon ↗

As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.

Side effects & interactions

Common side effects

  • Itching
  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Lion's Mane Erinacines use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
  • Alpha-GPC or CDP-cholineProvides choline substrate for acetylcholine synthesis.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Lion's Mane Erinacines — May improve mild cognitive impairment ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Lion's Mane Erinacines and "May improve mild cognitive impairment". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Lion's Mane Erinacines — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Lion's Mane Erinacines and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Lion's Mane Erinacines — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Lion's Mane Erinacines and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

Loading discussion…