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evidence · mechanism · dose
Supplements/Amino Acid

L-Histidine

Conditionally essential amino acid for hemoglobin.

General Wellness

Overview

Conditionally essential amino acid for hemoglobin.

Natural sources
    Common forms

      Mechanism of action

      Precursor to histamine and carnosine.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        May reduce RA symptoms

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1–4 g

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Amino Acid
            L-Histidine
            Amazon
            Wide selection · fast shipping
            Amino Acid
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            iHerb
            Global delivery · curated brands
            Amino Acid
            L-Histidine
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTArthritis Rheum · 1977

            Histidine in rheumatoid arthritis

            Pinals RS, et al.

            45 RA patients

            Key findings

            Modest improvement in grip strength.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Histidine — May reduce RA symptoms

            Live PubMed search

            Live results for "L-Histidine May reduce RA symptoms" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Histidine and "May reduce RA symptoms". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Histidine — randomized controlled trial

            Live PubMed search

            Live results for "L-Histidine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Histidine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Histidine — meta-analysis

            Live PubMed search

            Live results for "L-Histidine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Histidine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Histidine — pharmacokinetics

            Live PubMed search

            Live results for "L-Histidine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Histidine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Histidine — safety adverse events

            Live PubMed search

            Live results for "L-Histidine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Histidine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Histidine — dose response

            Live PubMed search

            Live results for "L-Histidine dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Histidine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: L-Histidine — clinical evidence

            Live Scholar search

            Cross-database citation index for L-Histidine as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.