GABA
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GABA. Primary inhibitory neurotransmitter; oral supplementation has limited CNS penetration.
How it works. Activates GABA-A and GABA-B receptors; oral GABA acts primarily on peripheral / enteric nervous system.
What the research supports. 1 graded claims. Strongest: Reduces subjective anxiety (small trials) (limited).
How much to take. Typical dose: 100–500 mg.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with Magnesium glycinate, L-theanine.
Forms. 1 forms. Pick one to open its profile.
Key studies. 8 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried GABA. Anecdotes are not medical advice.
GABA. Primary inhibitory neurotransmitter; oral supplementation has limited CNS penetration.
What it is
Primary inhibitory neurotransmitter; oral supplementation has limited CNS penetration.
Also called
Food sources
Goals
How it works
Activates GABA-A and GABA-B receptors; oral GABA acts primarily on peripheral / enteric nervous system.
Pathways
- GABAergic inhibition
Effects
- ↑Subjective relaxation increases
- ↑Alpha EEG increases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Tingling
- Mild drowsiness
Medication interactions
Theoretical additive sedation.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- Magnesium glycinateComplementary GABAergic calming and improved sleep architecture.
- L-theanineReduces sleep latency without sedation.
Forms
Key studies
8 studies cited in total.
Opens current human and preclinical literature matching GABA and "Reduces subjective anxiety". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching GABA and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching GABA and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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