Supplement Scholar
Compound

DIM (Diindolylmethane)

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DIM (Diindolylmethane). Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.

How it works. Modulates CYP1A1/1B1 ratio favoring 2-hydroxyestrone metabolism.

What the research supports. 2 graded claims. Strongest: Modulates estrogen metabolism (moderate).

How much to take. Typical dose: 100–200 mg/d.

Side effects and interactions. 2 medication interactions listed. No serious side effects listed at normal doses.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as DIM standardized, BR-DIM (bioavailable).

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried DIM (Diindolylmethane). Anecdotes are not medical advice.

DIM (Diindolylmethane). Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.

Key compound: 3,3'-diindolylmethaneC17H14N2 · 246.31 g/mol

What it is

Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.

Food sources

Cruciferous vegetables (via I3C)

Goals

Hormone OptimizationWomen's HealthMen's Health

How it works

Modulates CYP1A1/1B1 ratio favoring 2-hydroxyestrone metabolism.

Pathways

  • Estrogen 2-OH pathway

Effects

  • +Favorable estrogen metabolism supports

What the research supports

Modulates estrogen metabolismmoderate
Improves cervical dysplasia regressionlimited

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
100–200 mg/d
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the dim standardized form.
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Side effects & interactions

Common side effects

  • Headache
  • Dark urine (harmless)

Medication interactions

Tamoxifen / hormone therapymoderate

Estrogen metabolism interaction.

CYP3A4 substratesmoderate

Induces CYP1A2.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • DIM standardized
  • BR-DIM (bioavailable)

Key studies

9 studies cited in total.

PubMed: DIM (Diindolylmethane) — Modulates estrogen metabolism ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching DIM (Diindolylmethane) and "Modulates estrogen metabolism". Filter by RCT, meta-analysis, or year on the results page.

PubMed: DIM (Diindolylmethane) — Improves cervical dysplasia regression ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching DIM (Diindolylmethane) and "Improves cervical dysplasia regression". Filter by RCT, meta-analysis, or year on the results page.

PubMed: DIM (Diindolylmethane) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching DIM (Diindolylmethane) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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