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Cordyceps CS-4

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Cordyceps CS-4. Standardized cultivated cordyceps for kidney and energy support.

How it works. Cordycepin and polysaccharides modulate AMPK and immune function.

What the research supports. 1 graded claims. Strongest: Improves renal function in CKD trials (moderate).

How much to take. Typical dose: 1–3 g CS-4.

Side effects and interactions. 1 medication interaction listed. Serious: Possible bleeding risk.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Cordyceps CS-4. Anecdotes are not medical advice.

Cordyceps CS-4. Standardized cultivated cordyceps for kidney and energy support.

Key compound: cordycepinC10H13N5O3 · 251.24 g/mol

What it is

Standardized cultivated cordyceps for kidney and energy support.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Energy ProductionAthletic Performance

How it works

Cordycepin and polysaccharides modulate AMPK and immune function.

Pathways

  • Cordycepin
  • polysaccharides modulate AMPK
  • immune function

Effects

  • +renal function in CKD trials supports

What the research supports

Improves renal function in CKD trialsmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
1–3 g CS-4
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith food
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Serious

  • Possible bleeding risk

Medication interactions

Prescription medications (general)minor

Always disclose Cordyceps CS-4 use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Cordyceps CS-4 — Improves renal function in CKD trials ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Cordyceps CS-4 and "Improves renal function in CKD trials". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Cordyceps CS-4 — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Cordyceps CS-4 and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Cordyceps CS-4 — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Cordyceps CS-4 and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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