Supplement Scholar
Mineral

Copper Bisglycinate

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Copper Bisglycinate. Chelated copper used to balance high-dose zinc supplementation.

How it works. Cofactor for SOD1, lysyl oxidase, and ceruloplasmin.

What the research supports. 1 graded claims. Strongest: Prevents zinc-induced copper deficiency (strong).

How much to take. Typical dose: 1–2 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Collagen peptides, Vitamin C.

Common forms. Available as Chelated form (glycinate, bisglycinate, citrate, malate), Inorganic salt (oxide, sulfate, chloride), Liquid ionic solution, Topical or transdermal preparation.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Copper Bisglycinate. Anecdotes are not medical advice.

Copper Bisglycinate. Chelated copper used to balance high-dose zinc supplementation.

Molecular structureC4H8CuN2O4 · 211.66 g/mol

What it is

Chelated copper used to balance high-dose zinc supplementation.

Food sources

Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)Fortified foods such as cereals, breads, plant milks, and table saltMineral supplements as chelates, citrates, glycinates, or inorganic salts

Goals

General WellnessSkin, Hair & Nails

How it works

Cofactor for SOD1, lysyl oxidase, and ceruloplasmin.

Pathways

  • Cofactor for SOD1, lysyl oxidase
  • and ceruloplasmin

Effects

  • ↓zinc-induced copper deficiency decreases

What the research supports

Prevents zinc-induced copper deficiencystrong

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
1–2 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith food
Best formMost evidence is based on the chelated form (glycinate, bisglycinate, citrate, malate) form.
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Side effects & interactions

Medication interactions

Prescription medications (general)minor

Always disclose Copper Bisglycinate use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
  • Vitamin CRequired cofactor for collagen hydroxylation.

Common forms

  • Chelated form (glycinate, bisglycinate, citrate, malate)
  • Inorganic salt (oxide, sulfate, chloride)
  • Liquid ionic solution
  • Topical or transdermal preparation

Key studies

8 studies cited in total.

PubMed: Copper Bisglycinate — Prevents zinc-induced copper deficiency ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Copper Bisglycinate and "Prevents zinc-induced copper deficiency". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Copper Bisglycinate — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Copper Bisglycinate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Copper Bisglycinate — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Copper Bisglycinate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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