Collagen + Vitamin C (Tendon Protocol)
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Collagen + Vitamin C (Tendon Protocol). 15 g hydrolyzed collagen + 50 mg vit C taken 60 min pre-rehab — Shaw 2017 protocol.
How it works. Spikes plasma glycine/proline + vit C cofactor; loaded tissue uses substrate for collagen synthesis.
What the research supports. 1 graded claims. Strongest: Doubles collagen synthesis pre-rehab (Shaw 2017) (moderate).
How much to take. Typical dose: 15 g collagen + 50 mg vit C 60 min pre-loading.
Side effects and interactions. 1 medication interaction listed. Serious: Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing.
Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).
Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.
Key studies. 8 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Collagen + Vitamin C (Tendon Protocol). Anecdotes are not medical advice.
Collagen + Vitamin C (Tendon Protocol). 15 g hydrolyzed collagen + 50 mg vit C taken 60 min pre-rehab — Shaw 2017 protocol.
What it is
15 g hydrolyzed collagen + 50 mg vit C taken 60 min pre-rehab — Shaw 2017 protocol.
Food sources
Goals
How it works
Spikes plasma glycine/proline + vit C cofactor; loaded tissue uses substrate for collagen synthesis.
Pathways
- Spikes plasma glycine/proline + vit C cofactor
- loaded tissue uses substrate for collagen synthesis
Effects
- +Doubles collagen synthesis pre-rehab (Shaw 2017) supports
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Collagen + Vitamin C (Tendon Protocol) is generally well-tolerated at evidence-based doses
- Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- Headache or transient fatigue reported by a small fraction of users
Serious
- Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Medication interactions
Always disclose Collagen + Vitamin C (Tendon Protocol) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
Common forms
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Key studies
8 studies cited in total.
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Discussion
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