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Supplements/Amino Acid

L-Citrulline (NO Production)

Arginine precursor — most efficient way to raise plasma arginine and NO.

Nitric Oxide ProductionBlood FlowErectile FunctionVascular HealthWorkout Pumps

Overview

Arginine precursor — most efficient way to raise plasma arginine and NO.

Natural sources
    Common forms

      Mechanism of action

      Converted to arginine in kidney; bypasses arginase, raising plasma arginine more than oral arginine.

      Pathways
      • · Urea cycle
      • · eNOS/NO

      Effects on the body

      Increases
      Nitric oxide
      Increases
      Plasma arginine

      Organ system effects

      Evidence-based benefits

      Improves BP and endothelial function

      Moderate evidence

      Improves ED

      Limited evidence

      Potential side effects

      Common
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            3–6 g/d
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            RCTInt J Cardiol · 2012

            L-citrulline supplementation improves arterial stiffness

            Ochiai M, et al.

            7-day RCT of 5.6 g L-citrulline in middle-aged men.

            Key findings

            Reduced brachial-ankle pulse wave velocity and central BP.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Citrulline (NO Production) — Improves BP and endothelial function

            Live PubMed search

            Live results for "L-Citrulline (NO Production) Improves BP and endothelial function" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Citrulline (NO Production) and "Improves BP and endothelial function". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Citrulline (NO Production) — Improves ED

            Live PubMed search

            Live results for "L-Citrulline (NO Production) Improves ED" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Citrulline (NO Production) and "Improves ED". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Citrulline (NO Production) — randomized controlled trial

            Live PubMed search

            Live results for "L-Citrulline (NO Production) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Citrulline (NO Production) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Citrulline (NO Production) — meta-analysis

            Live PubMed search

            Live results for "L-Citrulline (NO Production) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Citrulline (NO Production) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Citrulline (NO Production) — pharmacokinetics

            Live PubMed search

            Live results for "L-Citrulline (NO Production) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Citrulline (NO Production) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Citrulline (NO Production) — safety adverse events

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            Live results for "L-Citrulline (NO Production) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Citrulline (NO Production) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Citrulline (NO Production) — dose response

            Live PubMed search

            Live results for "L-Citrulline (NO Production) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Citrulline (NO Production) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: L-Citrulline (NO Production) — clinical evidence

            Live Scholar search

            Cross-database citation index for L-Citrulline (NO Production) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.