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Herb

Chamomile

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Chamomile. Gentle anxiolytic and sleep-supportive herb.

How it works. Apigenin binds benzodiazepine site of GABA-A receptor.

What the research supports. 1 graded claims. Strongest: Reduces GAD symptoms (long-term RCTs) (moderate).

How much to take. Typical dose: 220–1100 mg standardized; or 2–3 cups tea.

Side effects and interactions. 1 medication interaction listed. Serious: Anaphylaxis (rare).

Stacking. Pairs well with Magnesium glycinate, L-theanine.

Forms. 1 forms. Pick one to open its profile.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Chamomile. Anecdotes are not medical advice.

Chamomile. Gentle anxiolytic and sleep-supportive herb.

Key compound: apigeninC15H10O5 · 270.24 g/mol

What it is

Gentle anxiolytic and sleep-supportive herb.

Also called

Matricaria recutita

Food sources

Matricaria recutita flower

Goals

Sleep & RecoveryMood & AnxietyGut Health

How it works

Apigenin binds benzodiazepine site of GABA-A receptor.

Pathways

  • GABA-A modulation

Effects

  • ↓Anxiety decreases

What the research supports

Reduces GAD symptoms (long-term RCTs)moderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
220–1100 mg standardized; or 2–3 cups tea
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the tea form.
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Side effects & interactions

Serious

  • Anaphylaxis (rare)

Medication interactions

Warfarinminor

Coumarins — mild interaction.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Key studies

8 studies cited in total.

PubMed: Chamomile — Reduces GAD symptoms ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Chamomile and "Reduces GAD symptoms". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Chamomile — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Chamomile and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Chamomile — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Chamomile and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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