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Herb

Centella asiatica (Skin)

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Centella asiatica (Skin). Standardized titrated extract for scars and venous skin changes.

How it works. Asiatic acid and madecassic acid stimulate fibroblast collagen and reduce TGF-β driven fibrosis.

What the research supports. 1 graded claims. Strongest: Reduces hypertrophic scarring (moderate).

How much to take. Typical dose: 60–120 mg TECA.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Collagen peptides, Vitamin C.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Centella asiatica (Skin). Anecdotes are not medical advice.

Centella asiatica (Skin). Standardized titrated extract for scars and venous skin changes.

Key compound: asiatic acidC30H48O5 · 488.7 g/mol

What it is

Standardized titrated extract for scars and venous skin changes.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Skin, Hair & Nails

How it works

Asiatic acid and madecassic acid stimulate fibroblast collagen and reduce TGF-β driven fibrosis.

Pathways

  • Asiatic acid
  • madecassic acid stimulate fibroblast collagen
  • reduce TGF-β driven fibrosis

Effects

  • ↓hypertrophic scarring decreases

What the research supports

Reduces hypertrophic scarringmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
60–120 mg TECA
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith food
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • Skin irritation

Medication interactions

Prescription medications (general)minor

Always disclose Centella asiatica (Skin) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
  • Vitamin CRequired cofactor for collagen hydroxylation.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Centella asiatica (Skin) — Reduces hypertrophic scarring ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Centella asiatica (Skin) and "Reduces hypertrophic scarring". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Centella asiatica (Skin) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Centella asiatica (Skin) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Centella asiatica (Skin) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Centella asiatica (Skin) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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