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evidence · mechanism · dose
Supplements/Compound

Calcium AKG (Alpha-Ketoglutarate)

TCA-cycle intermediate — extended lifespan in C. elegans; emerging human data on biological age.

Longevity PathwaysBiological AgeHealthy Aging (alias)Muscle Preservation

Overview

TCA-cycle intermediate — extended lifespan in C. elegans; emerging human data on biological age.

Natural sources
    Common forms

      Mechanism of action

      Co-substrate for α-KG-dependent dioxygenases (TET, JMJD); modulates DNA/histone demethylation.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduced biological age 8y in 7 months (open-label TruDiagnostic)

        Limited evidence

        Lifespan extension in C. elegans/mice

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              1000 mg Ca-AKG /d (sustained-release)
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Calcium AKG …
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              Global delivery · curated brands
              Compound
              Calcium AKG …
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (9)

              AnimalCell Metab · 2020

              Alpha-ketoglutarate on lifespan and frailty

              Asadi Shahmirzadi A, et al.

              Mouse study of Ca-AKG on healthspan.

              Key findings

              Extended healthspan and reduced frailty markers.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Calcium AKG (Alpha-Ketoglutarate) — Reduced biological age 8y in 7 months

              Live PubMed search

              Live results for "Calcium AKG (Alpha-Ketoglutarate) Reduced biological age 8y in 7 months" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "Reduced biological age 8y in 7 months". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Calcium AKG (Alpha-Ketoglutarate) — Lifespan extension in C. elegans/mice

              Live PubMed search

              Live results for "Calcium AKG (Alpha-Ketoglutarate) Lifespan extension in C. elegans/mice" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "Lifespan extension in C. elegans/mice". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Calcium AKG (Alpha-Ketoglutarate) — randomized controlled trial

              Live PubMed search

              Live results for "Calcium AKG (Alpha-Ketoglutarate) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Calcium AKG (Alpha-Ketoglutarate) — meta-analysis

              Live PubMed search

              Live results for "Calcium AKG (Alpha-Ketoglutarate) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Calcium AKG (Alpha-Ketoglutarate) — pharmacokinetics

              Live PubMed search

              Live results for "Calcium AKG (Alpha-Ketoglutarate) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Calcium AKG (Alpha-Ketoglutarate) — safety adverse events

              Live PubMed search

              Live results for "Calcium AKG (Alpha-Ketoglutarate) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Calcium AKG (Alpha-Ketoglutarate) — dose response

              Live PubMed search

              Live results for "Calcium AKG (Alpha-Ketoglutarate) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Calcium AKG (Alpha-Ketoglutarate) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Calcium AKG (Alpha-Ketoglutarate) — clinical evidence

              Live Scholar search

              Cross-database citation index for Calcium AKG (Alpha-Ketoglutarate) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.