Overview
TCA-cycle intermediate — extended lifespan in C. elegans; emerging human data on biological age.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Co-substrate for α-KG-dependent dioxygenases (TET, JMJD); modulates DNA/histone demethylation.
- · Co-substrate for α-KG-dependent dioxygenases (TET, JMJD)
- · modulates DNA/histone demethylation
Effects on the body
Organ system effects
Evidence-based benefits
Reduced biological age 8y in 7 months (open-label TruDiagnostic)
Limited evidenceLifespan extension in C. elegans/mice
Moderate evidencePotential side effects
- · Calcium AKG (Alpha-Ketoglutarate) is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Calcium AKG (Alpha-Ketoglutarate) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Calcium AKG (Alpha-Ketoglutarate) third party tested NSF
CapsulesPre-measured Calcium AKG (Alpha-Ketoglutarate) capsules — easiest for travel and consistent daily dosing without scoops or scales.Calcium AKG (Alpha-Ketoglutarate) capsules
PowderBulk unflavored Calcium AKG (Alpha-Ketoglutarate) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Calcium AKG (Alpha-Ketoglutarate) powder unflavored
Best sellersMost-purchased Calcium AKG (Alpha-Ketoglutarate) products on Amazon — a quick way to see what's reviewed widely before you commit.Calcium AKG (Alpha-Ketoglutarate) best sellerScientific evidence9Show studiesHide studies
Alpha-ketoglutarate on lifespan and frailty
Asadi Shahmirzadi A, et al.
Mouse study of Ca-AKG on healthspan.
Extended healthspan and reduced frailty markers.
PubMed: Calcium AKG (Alpha-Ketoglutarate) — Reduced biological age 8y in 7 months
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PubMed: Calcium AKG (Alpha-Ketoglutarate) — Lifespan extension in C. elegans/mice
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PubMed: Calcium AKG (Alpha-Ketoglutarate) — safety adverse events
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PubMed: Calcium AKG (Alpha-Ketoglutarate) — dose response
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Google Scholar: Calcium AKG (Alpha-Ketoglutarate) — clinical evidence
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