Supplement Scholar
Herb

Ashwagandha KSM-66

Buy on Amazon ↗

Affiliate link: we may earn a commission at no extra cost to you. Disclosures

Ashwagandha KSM-66. Standardized Withania somnifera root extract for stress.

How it works. Withanolides modulate HPA axis and reduce cortisol.

What the research supports. 1 graded claims. Strongest: Reduces cortisol, improves strength (moderate).

How much to take. Typical dose: 600 mg KSM-66.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Ashwagandha KSM-66. Anecdotes are not medical advice.

Ashwagandha KSM-66. Standardized Withania somnifera root extract for stress.

Key compound: withaferin AC28H38O6 · 470.6 g/mol

What it is

Standardized Withania somnifera root extract for stress.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Mood & Anxiety

How it works

Withanolides modulate HPA axis and reduce cortisol.

Pathways

  • Withanolides modulate HPA axis
  • reduce cortisol

Effects

  • ↓cortisol, improves strength decreases

What the research supports

Reduces cortisol, improves strengthmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
600 mg KSM-66
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the standardized extract capsule form.
Shop Ashwagandha KSM-66 on Amazon ↗

As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.

Side effects & interactions

Common side effects

  • GI upset
  • Drowsiness

Medication interactions

Prescription medications (general)minor

Always disclose Ashwagandha KSM-66 use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Ashwagandha KSM-66 — Reduces cortisol, improves strength ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Ashwagandha KSM-66 and "Reduces cortisol, improves strength". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Ashwagandha KSM-66 — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Ashwagandha KSM-66 and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Ashwagandha KSM-66 — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Ashwagandha KSM-66 and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

Loading discussion…