Supplement Scholar
GH Secretagogue

GHRP-2

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

GHRP-2. Second-generation ghrelin mimetic that drives pulsatile pituitary GH release.

How it works. Activates GHS-R1a on somatotrophs while suppressing somatostatin tone, amplifying endogenous GH pulses.

What the research supports. 3 graded claims. Strongest: Used in GH-deficiency stimulation testing (preclinical).

Hormonal impact. Effects on Growth hormone, IGF-1, Cortisol, Prolactin.

Side effects and interactions. 1 medication interaction listed. Serious: Insulin resistance and HPA disruption with chronic use.

Stacking. Pairs well with CJC-1295. Avoid combining with Active malignancy.

Common forms. Available as Subcutaneous injection, Intranasal (compounded).

Community. Experiences from people who have tried GHRP-2. Anecdotes are not medical advice.

GHRP-2. Second-generation ghrelin mimetic that drives pulsatile pituitary GH release.

Molecular structureC45H55N9O6 · 818.0 g/mol

What it is

GHRP-2 is a synthetic hexapeptide that binds the growth-hormone secretagogue receptor (GHS-R1a), producing sharp GH pulses with modest cortisol and prolactin spillover.

Also called

PralmorelinKP-102

How it works

Activates GHS-R1a on somatotrophs while suppressing somatostatin tone, amplifying endogenous GH pulses.

Pathways

  • GHS-R1a activation
  • Somatostatin suppression

Effects

  • ↑Endogenous GH pulses increases
  • +Lean tissue repair supports
  • ↑Appetite increases

What the research supports

Used in GH-deficiency stimulation testingpreclinical
Anecdotal recovery and sleep-depth improvementspreclinical
Larger pulses than GHRH alonepreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑Growth hormoneincreases
↑IGF-1increases
↑Cortisolincreases
↑Prolactinincreases

Side effects & interactions

Common side effects

  • Hunger
  • Flushing
  • Lethargy after dosing

Serious

  • Insulin resistance and HPA disruption with chronic use

Medication interactions

Insulinmoderate

Altered glucose handling at higher doses.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • CJC-1295GHRH + GHRP synergy produces a larger, cleaner GH pulse.

Avoid combining

  • Active malignancyRaising IGF-1 is generally contraindicated.

Common forms

  • Subcutaneous injection
  • Intranasal (compounded)

Discussion

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