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Compound

Zinc Carnosine

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Zinc Carnosine. Japanese ulcer drug binding zinc to L-carnosine for mucosal repair.

How it works. Adheres to ulcerated mucosa, releases zinc/carnosine to support epithelial repair.

What the research supports. 2 graded claims. Strongest: Heals H. pylori-related ulcers (strong).

How much to take. Typical dose: 75 mg bid (≈16 mg zinc).

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 9 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Zinc Carnosine. Anecdotes are not medical advice.

Zinc Carnosine. Japanese ulcer drug binding zinc to L-carnosine for mucosal repair.

Molecular structureC9H12N4O3Zn · 289.6 g/mol

What it is

Japanese ulcer drug binding zinc to L-carnosine for mucosal repair.

Also called

Polaprezinc

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

How it works

Adheres to ulcerated mucosa, releases zinc/carnosine to support epithelial repair.

Pathways

  • Adheres to ulcerated mucosa, releases zinc/carnosine to support epithelial repair

Effects

  • +Heals H. pylori-related ulcers supports
  • ↓NSAID-induced gut permeability decreases

What the research supports

Heals H. pylori-related ulcersstrong
Reduces NSAID-induced gut permeabilitymoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
75 mg bid (≈16 mg zinc)
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Constipation

Medication interactions

Prescription medications (general)minor

Always disclose Zinc Carnosine use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

9 studies cited in total.

PubMed: Zinc Carnosine — Heals H. pylori-related ulcers ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Zinc Carnosine and "Heals H. pylori-related ulcers". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Zinc Carnosine — Reduces NSAID-induced gut permeability ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Zinc Carnosine and "Reduces NSAID-induced gut permeability". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Zinc Carnosine — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Zinc Carnosine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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