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Supplements/Mineral

Polaprezinc

Japanese ulcer treatment.

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Overview

Japanese ulcer treatment.

Natural sources
  • Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)
  • Fortified foods such as cereals, breads, plant milks, and table salt
  • Mineral supplements as chelates, citrates, glycinates, or inorganic salts
Common forms
  • Chelated form (glycinate, bisglycinate, citrate, malate)
  • Inorganic salt (oxide, sulfate, chloride)
  • Liquid ionic solution
  • Topical or transdermal preparation

Mechanism of action

Zinc-carnosine chelate adheres to ulcers.

Pathways
  • · Zinc-carnosine chelate adheres to ulcers

Effects on the body

Supports
Heals gastric ulcers

Organ system effects

Digestive / Gut

Polaprezinc influences gut motility, mucosal integrity, or microbial balance in the GI tract.

Evidence-based benefits

Heals gastric ulcers

Moderate evidence

Potential side effects

Common
  • · Metallic taste
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Polaprezinc use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Multi-strain probiotic
        Supports microbiome diversity and barrier integrity.
      • L-glutamine
        Substrate for enterocyte energy and tight-junction maintenance.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      75 mg BID
      Best form
      Most evidence is based on the chelated form (glycinate, bisglycinate, citrate, malate) form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      In vitroBiochemistry · 2000

      Polaprezinc for ulcers

      Matsukura T, Tanaka H

      Mechanism

      Key findings

      Adheres to ulcer base and accelerates healing.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Polaprezinc — Heals gastric ulcers

      Live PubMed search

      Live results for "Polaprezinc Heals gastric ulcers" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Polaprezinc and "Heals gastric ulcers". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Polaprezinc — randomized controlled trial

      Live PubMed search

      Live results for "Polaprezinc randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Polaprezinc and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Polaprezinc — meta-analysis

      Live PubMed search

      Live results for "Polaprezinc meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Polaprezinc and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Polaprezinc — pharmacokinetics

      Live PubMed search

      Live results for "Polaprezinc pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Polaprezinc and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Polaprezinc — safety adverse events

      Live PubMed search

      Live results for "Polaprezinc safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Polaprezinc and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Polaprezinc — dose response

      Live PubMed search

      Live results for "Polaprezinc dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Polaprezinc and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Polaprezinc — clinical evidence

      Live Scholar search

      Cross-database citation index for Polaprezinc as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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