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Supplements/Compound

Zinc Carnosine

aka Polaprezinc

Japanese ulcer drug binding zinc to L-carnosine for mucosal repair.

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Overview

Japanese ulcer drug binding zinc to L-carnosine for mucosal repair.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Adheres to ulcerated mucosa, releases zinc/carnosine to support epithelial repair.

Pathways
  • · Adheres to ulcerated mucosa, releases zinc/carnosine to support epithelial repair

Effects on the body

Supports
Heals H. pylori-related ulcers
Decreases
NSAID-induced gut permeability

Organ system effects

Evidence-based benefits

Heals H. pylori-related ulcers

Strong evidence

Reduces NSAID-induced gut permeability

Moderate evidence

Potential side effects

Common
  • · Constipation
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Zinc Carnosine use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • A high-quality multivitamin
        Covers micronutrient cofactors that support most supplement pathways.
      • Omega-3 (EPA/DHA)
        Foundational anti-inflammatory support that complements most regimens.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      75 mg bid (≈16 mg zinc)
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence9Show studies
      RCTGut · 2007

      Zinc carnosine on intestinal permeability

      Mahmood A, et al.

      Crossover RCT during indomethacin challenge.

      Key findings

      Prevented NSAID-induced increase in small bowel permeability.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc Carnosine — Heals H. pylori-related ulcers

      Live PubMed search

      Live results for "Zinc Carnosine Heals H. pylori-related ulcers" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc Carnosine and "Heals H. pylori-related ulcers". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc Carnosine — Reduces NSAID-induced gut permeability

      Live PubMed search

      Live results for "Zinc Carnosine Reduces NSAID-induced gut permeability" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc Carnosine and "Reduces NSAID-induced gut permeability". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc Carnosine — randomized controlled trial

      Live PubMed search

      Live results for "Zinc Carnosine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc Carnosine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc Carnosine — meta-analysis

      Live PubMed search

      Live results for "Zinc Carnosine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc Carnosine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc Carnosine — pharmacokinetics

      Live PubMed search

      Live results for "Zinc Carnosine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc Carnosine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc Carnosine — safety adverse events

      Live PubMed search

      Live results for "Zinc Carnosine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc Carnosine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc Carnosine — dose response

      Live PubMed search

      Live results for "Zinc Carnosine dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc Carnosine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Zinc Carnosine — clinical evidence

      Live Scholar search

      Cross-database citation index for Zinc Carnosine as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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