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evidence · mechanism · dose
Supplements/Compound

Zinc Carnosine

aka Polaprezinc

Japanese ulcer drug binding zinc to L-carnosine for mucosal repair.

Overview

Japanese ulcer drug binding zinc to L-carnosine for mucosal repair.

Natural sources
    Common forms

      Mechanism of action

      Adheres to ulcerated mucosa, releases zinc/carnosine to support epithelial repair.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Heals H. pylori-related ulcers

        Strong evidence

        Reduces NSAID-induced gut permeability

        Moderate evidence

        Potential side effects

        Common
        • · Constipation
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            75 mg bid (≈16 mg zinc)
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Zinc Carnosine
            Amazon
            Wide selection · fast shipping
            Compound
            Zinc Carnosine
            iHerb
            Global delivery · curated brands
            Compound
            Zinc Carnosine
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            RCTGut · 2007

            Zinc carnosine on intestinal permeability

            Mahmood A, et al.

            Crossover RCT during indomethacin challenge.

            Key findings

            Prevented NSAID-induced increase in small bowel permeability.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Carnosine — Heals H. pylori-related ulcers

            Live PubMed search

            Live results for "Zinc Carnosine Heals H. pylori-related ulcers" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Carnosine and "Heals H. pylori-related ulcers". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Carnosine — Reduces NSAID-induced gut permeability

            Live PubMed search

            Live results for "Zinc Carnosine Reduces NSAID-induced gut permeability" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Carnosine and "Reduces NSAID-induced gut permeability". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Carnosine — randomized controlled trial

            Live PubMed search

            Live results for "Zinc Carnosine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Carnosine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Carnosine — meta-analysis

            Live PubMed search

            Live results for "Zinc Carnosine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Carnosine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Carnosine — pharmacokinetics

            Live PubMed search

            Live results for "Zinc Carnosine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Carnosine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Carnosine — safety adverse events

            Live PubMed search

            Live results for "Zinc Carnosine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Carnosine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Zinc Carnosine — dose response

            Live PubMed search

            Live results for "Zinc Carnosine dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Zinc Carnosine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Zinc Carnosine — clinical evidence

            Live Scholar search

            Cross-database citation index for Zinc Carnosine as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.