Zinc Bisglycinate
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Zinc Bisglycinate. Glycine-chelated zinc — high absorption and very gentle on the stomach.
How it works. Chelated to two glycines, absorbed via amino acid transporters.
What the research supports. 1 graded claims. Strongest: Equivalent or better absorption vs picolinate, fewer GI complaints (limited).
How much to take. Typical dose: 15–30 mg elemental.
Side effects and interactions. 1 medication interaction listed. Serious: Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing.
Stacking. Pairs well with Vitamin D3 + K2, Zinc, Collagen peptides.
Common forms. Available as Chelated form (glycinate, bisglycinate, citrate, malate), Inorganic salt (oxide, sulfate, chloride), Liquid ionic solution, Topical or transdermal preparation.
Key studies. 8 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried Zinc Bisglycinate. Anecdotes are not medical advice.
Zinc Bisglycinate. Glycine-chelated zinc — high absorption and very gentle on the stomach.
What it is
Glycine-chelated zinc — high absorption and very gentle on the stomach.
Food sources
Goals
How it works
Chelated to two glycines, absorbed via amino acid transporters.
Pathways
- Zn enzymes
- Immune signaling
Effects
- +Equivalent or better absorption vs picolinate, fewer GI complaints supports
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- Zinc Bisglycinate is generally well-tolerated at evidence-based doses
- Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- Headache or transient fatigue reported by a small fraction of users
Serious
- Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Medication interactions
Always disclose Zinc Bisglycinate use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- Vitamin D3 + K2Foundational immune modulation.
- ZincRequired cofactor for innate and adaptive immune function.
- Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
Common forms
- Chelated form (glycinate, bisglycinate, citrate, malate)
- Inorganic salt (oxide, sulfate, chloride)
- Liquid ionic solution
- Topical or transdermal preparation
Key studies
8 studies cited in total.
Opens current human and preclinical literature matching Zinc Bisglycinate and "Equivalent or better absorption vs picolinate, fewer GI complaints". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Zinc Bisglycinate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching Zinc Bisglycinate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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