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evidence · mechanism · dose
Supplements/Herb

White Willow Bark

Salix alba salicin for pain and inflammation.

Overview

Salix alba salicin for pain and inflammation.

Natural sources
    Common forms

      Mechanism of action

      Salicin metabolized to salicylic acid.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces back pain

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        • · Bleeding risk
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            240 mg salicin

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            White Willow…
            Amazon
            Wide selection · fast shipping
            Herb
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            iHerb
            Global delivery · curated brands
            Herb
            White Willow…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTAm J Med · 2000

            Willow bark for back pain

            Chrubasik S, et al.

            210 back pain patients

            Key findings

            Dose-dependent pain relief.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: White Willow Bark — Reduces back pain

            Live PubMed search

            Live results for "White Willow Bark Reduces back pain" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching White Willow Bark and "Reduces back pain". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: White Willow Bark — randomized controlled trial

            Live PubMed search

            Live results for "White Willow Bark randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching White Willow Bark and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: White Willow Bark — meta-analysis

            Live PubMed search

            Live results for "White Willow Bark meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching White Willow Bark and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: White Willow Bark — pharmacokinetics

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: White Willow Bark — safety adverse events

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: White Willow Bark — dose response

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            Key findings

            Opens current human and preclinical literature matching White Willow Bark and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: White Willow Bark — clinical evidence

            Live Scholar search

            Cross-database citation index for White Willow Bark as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.