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evidence · mechanism · dose
Supplements/Compound

UC-II Undenatured Type II Collagen

Oral tolerance for joint health.

Overview

Oral tolerance for joint health.

Natural sources
    Common forms

      Mechanism of action

      Induces oral tolerance to type II collagen.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces OA pain

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            40 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            UC-II Undena…
            Amazon
            Wide selection · fast shipping
            Compound
            UC-II Undena…
            iHerb
            Global delivery · curated brands
            Compound
            UC-II Undena…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTNutr J · 2016

            UC-II for OA

            Lugo JP, et al.

            191 OA patients

            Key findings

            Reduced WOMAC score vs glucosamine+chondroitin.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: UC-II Undenatured Type II Collagen — Reduces OA pain

            Live PubMed search

            Live results for "UC-II Undenatured Type II Collagen Reduces OA pain" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching UC-II Undenatured Type II Collagen and "Reduces OA pain". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: UC-II Undenatured Type II Collagen — randomized controlled trial

            Live PubMed search

            Live results for "UC-II Undenatured Type II Collagen randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching UC-II Undenatured Type II Collagen and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: UC-II Undenatured Type II Collagen — meta-analysis

            Live PubMed search

            Live results for "UC-II Undenatured Type II Collagen meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching UC-II Undenatured Type II Collagen and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: UC-II Undenatured Type II Collagen — pharmacokinetics

            Live PubMed search

            Live results for "UC-II Undenatured Type II Collagen pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching UC-II Undenatured Type II Collagen and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: UC-II Undenatured Type II Collagen — safety adverse events

            Live PubMed search

            Live results for "UC-II Undenatured Type II Collagen safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching UC-II Undenatured Type II Collagen and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: UC-II Undenatured Type II Collagen — dose response

            Live PubMed search

            Live results for "UC-II Undenatured Type II Collagen dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching UC-II Undenatured Type II Collagen and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: UC-II Undenatured Type II Collagen — clinical evidence

            Live Scholar search

            Cross-database citation index for UC-II Undenatured Type II Collagen as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.