Supplement Scholar
Peptide

TB-500 (Thymosin Beta-4)

Prescription drug or research compound. Use only under the care of a licensed prescriber. Information here is educational and not a recommendation to obtain or use it.

TB-500 (Thymosin Beta-4). Synthetic thymosin fragment for tissue repair.

How it works. Sequesters G-actin, promotes angiogenesis and cell migration.

What the research supports. 1 graded claims. Strongest: Accelerates wound healing (moderate).

How much to take. Typical dose: 2 mg subcutaneous twice weekly.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Collagen peptides, Vitamin C.

Common forms. Available as Subcutaneous injection, Oral or sublingual lozenge, Nasal spray, Compounded topical.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried TB-500 (Thymosin Beta-4). Anecdotes are not medical advice.

TB-500 (Thymosin Beta-4). Synthetic thymosin fragment for tissue repair.

7-residue chainC38H68N10O14 · 889.0 g/mol

What it is

Synthetic thymosin fragment for tissue repair.

Food sources

Synthetic peptide manufactured to pharmaceutical or research-grade puritySubcutaneous injection, sublingual, or oral preparation depending on bioavailabilityCompounded by a licensed pharmacy for clinical use

Goals

Skin, Hair & Nails

How it works

Sequesters G-actin, promotes angiogenesis and cell migration.

Pathways

  • Sequesters G-actin, promotes angiogenesis
  • cell migration

Effects

  • +Accelerates wound healing supports

What the research supports

Accelerates wound healingmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
2 mg subcutaneous twice weekly
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the subcutaneous injection form.

Side effects & interactions

Common side effects

  • Injection site pain

Medication interactions

Prescription medications (general)minor

Always disclose TB-500 (Thymosin Beta-4) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
  • Vitamin CRequired cofactor for collagen hydroxylation.

Common forms

  • Subcutaneous injection
  • Oral or sublingual lozenge
  • Nasal spray
  • Compounded topical

Key studies

8 studies cited in total.

PubMed: TB-500 (Thymosin Beta-4) — Accelerates wound healing ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "Accelerates wound healing". Filter by RCT, meta-analysis, or year on the results page.

PubMed: TB-500 (Thymosin Beta-4) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: TB-500 (Thymosin Beta-4) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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