Overview
Short-chain fatty acid for colon health.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Primary colonocyte fuel; HDAC inhibitor.
- · Primary colonocyte fuel
- · HDAC inhibitor
Effects on the body
Organ system effects
Sodium Butyrate influences gut motility, mucosal integrity, or microbial balance in the GI tract.
Evidence-based benefits
Anti-inflammatory
Moderate evidencePotential side effects
- · Bad smell
Drug interactions
Supplement interactions
- Multi-strain probioticSupports microbiome diversity and barrier integrity.
- L-glutamineSubstrate for enterocyte energy and tight-junction maintenance.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Sodium Butyrate — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Sodium Butyrate third party tested NSF
CapsulesPre-measured Sodium Butyrate capsules — easiest for travel and consistent daily dosing without scoops or scales.Sodium Butyrate capsules
PowderBulk unflavored Sodium Butyrate powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Sodium Butyrate powder unflavored
Best sellersMost-purchased Sodium Butyrate products on Amazon — a quick way to see what's reviewed widely before you commit.Sodium Butyrate best sellerScientific evidence8Show studiesHide studies
Butyrate in ulcerative colitis
Hamer HM, et al.
Mechanistic review
Anti-inflammatory effects via HDAC inhibition.
PubMed: Sodium Butyrate — Anti-inflammatory
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PubMed: Sodium Butyrate — dose response
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Google Scholar: Sodium Butyrate — clinical evidence
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