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SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

Sodium Butyrate

Short-chain fatty acid for colon health.

Overview

Short-chain fatty acid for colon health.

Natural sources
    Common forms

      Mechanism of action

      Primary colonocyte fuel; HDAC inhibitor.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Anti-inflammatory

        Moderate evidence

        Potential side effects

        Common
        • · Bad smell
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300–600 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Sodium Butyr…
            Amazon
            Wide selection · fast shipping
            Compound
            Sodium Butyr…
            iHerb
            Global delivery · curated brands
            Compound
            Sodium Butyr…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewAliment Pharmacol Ther · 2008

            Butyrate in ulcerative colitis

            Hamer HM, et al.

            Mechanistic review

            Key findings

            Anti-inflammatory effects via HDAC inhibition.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Butyrate — Anti-inflammatory

            Live PubMed search

            Live results for "Sodium Butyrate Anti-inflammatory" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Butyrate and "Anti-inflammatory". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Butyrate — randomized controlled trial

            Live PubMed search

            Live results for "Sodium Butyrate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Butyrate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Butyrate — meta-analysis

            Live PubMed search

            Live results for "Sodium Butyrate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Butyrate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Butyrate — pharmacokinetics

            Live PubMed search

            Live results for "Sodium Butyrate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Butyrate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Butyrate — safety adverse events

            Live PubMed search

            Live results for "Sodium Butyrate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Butyrate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Sodium Butyrate — dose response

            Live PubMed search

            Live results for "Sodium Butyrate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Sodium Butyrate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Sodium Butyrate — clinical evidence

            Live Scholar search

            Cross-database citation index for Sodium Butyrate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.