Supplement Scholar
Compound

Rebamipide

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Rebamipide. Mucosal protective for gastritis.

How it works. Increases prostaglandins and mucus secretion.

What the research supports. 1 graded claims. Strongest: Prevents NSAID gastropathy (moderate).

How much to take. Typical dose: 100 mg TID.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Multi-strain probiotic, L-glutamine.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Rebamipide. Anecdotes are not medical advice.

Rebamipide. Mucosal protective for gastritis.

Molecular structureC19H15ClN2O4 · 370.8 g/mol

What it is

Mucosal protective for gastritis.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

How it works

Increases prostaglandins and mucus secretion.

Pathways

  • Increases prostaglandins
  • mucus secretion

Effects

  • ↓NSAID gastropathy decreases

What the research supports

Prevents NSAID gastropathymoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
100 mg TID
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Constipation

Medication interactions

Prescription medications (general)minor

Always disclose Rebamipide use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Rebamipide — Prevents NSAID gastropathy ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rebamipide and "Prevents NSAID gastropathy". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Rebamipide — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rebamipide and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Rebamipide — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Rebamipide and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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