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evidence · mechanism · dose
Supplements/Compound

Papain

Papaya proteolytic enzyme.

Overview

Papaya proteolytic enzyme.

Natural sources
    Common forms

      Mechanism of action

      Cleaves proteins; anti-inflammatory.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Digestion support

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            100–200 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Papain
            Amazon
            Wide selection · fast shipping
            Compound
            Papain
            iHerb
            Global delivery · curated brands
            Compound
            Papain
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewTrans Am Clin Climatol Assoc · 2004

            Papain for digestion

            Pina IL, et al.

            Pharmacological review

            Key findings

            Useful as digestive aid.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Papain — Digestion support

            Live PubMed search

            Live results for "Papain Digestion support" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Papain and "Digestion support". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Papain — randomized controlled trial

            Live PubMed search

            Live results for "Papain randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Papain and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Papain — meta-analysis

            Live PubMed search

            Live results for "Papain meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Papain and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Papain — pharmacokinetics

            Live PubMed search

            Live results for "Papain pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Papain and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Papain — safety adverse events

            Live PubMed search

            Live results for "Papain safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Papain and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Papain — dose response

            Live PubMed search

            Live results for "Papain dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Papain and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Papain — clinical evidence

            Live Scholar search

            Cross-database citation index for Papain as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.