Overview
Endogenous lipid for appetite regulation.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Activates PPAR-α; reduces food intake via vagal afferents.
- · Activates PPAR-α
- · reduces food intake via vagal afferents
Effects on the body
Organ system effects
OEA (Oleoylethanolamide) affects hepatic insulin sensitivity, lipid handling, or glucose disposal.
Evidence-based benefits
Reduces appetite
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified OEA (Oleoylethanolamide) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.OEA (Oleoylethanolamide) third party tested NSF
CapsulesPre-measured OEA (Oleoylethanolamide) capsules — easiest for travel and consistent daily dosing without scoops or scales.OEA (Oleoylethanolamide) capsules
PowderBulk unflavored OEA (Oleoylethanolamide) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.OEA (Oleoylethanolamide) powder unflavored
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OEA satiety
Fu J, et al.
Rodents
Reduced food intake and body weight.
PubMed: OEA (Oleoylethanolamide) — Reduces appetite
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