Supplement Scholar
Compound

Naringenin

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Naringenin. Grapefruit flavonoid for metabolic health.

How it works. Activates PPAR-α and inhibits HMG-CoA reductase.

What the research supports. 1 graded claims. Strongest: Lowers cholesterol (preclinical) (moderate).

How much to take. Typical dose: 200–500 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Naringenin. Anecdotes are not medical advice.

Naringenin. Grapefruit flavonoid for metabolic health.

Molecular structureC15H12O5 · 272.25 g/mol

What it is

Grapefruit flavonoid for metabolic health.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

How it works

Activates PPAR-α and inhibits HMG-CoA reductase.

Pathways

  • Activates PPAR-α
  • inhibits HMG-CoA reductase

Effects

  • ↓cholesterol (preclinical) decreases

What the research supports

Lowers cholesterol (preclinical)moderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
200–500 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • CYP3A4 inhibition

Medication interactions

Prescription medications (general)minor

Always disclose Naringenin use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Naringenin — Lowers cholesterol ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Naringenin and "Lowers cholesterol". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Naringenin — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Naringenin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Naringenin — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Naringenin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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