Overview
Grapefruit flavonoid for metabolic health.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Activates PPAR-α and inhibits HMG-CoA reductase.
- · Activates PPAR-α
- · inhibits HMG-CoA reductase
Effects on the body
Organ system effects
Naringenin affects hepatic insulin sensitivity, lipid handling, or glucose disposal.
Evidence-based benefits
Lowers cholesterol (preclinical)
Moderate evidencePotential side effects
- · CYP3A4 inhibition
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Naringenin — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Naringenin third party tested NSF
CapsulesPre-measured Naringenin capsules — easiest for travel and consistent daily dosing without scoops or scales.Naringenin capsules
PowderBulk unflavored Naringenin powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Naringenin powder unflavored
Best sellersMost-purchased Naringenin products on Amazon — a quick way to see what's reviewed widely before you commit.Naringenin best sellerScientific evidence8Show studiesHide studies
Naringenin and metabolic syndrome
Mulvihill EE, et al.
LDLR-/- mice
Prevented dyslipidemia and atherosclerosis.
PubMed: Naringenin — Lowers cholesterol
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PubMed: Naringenin — randomized controlled trial
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PubMed: Naringenin — meta-analysis
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PubMed: Naringenin — pharmacokinetics
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PubMed: Naringenin — safety adverse events
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PubMed: Naringenin — dose response
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Google Scholar: Naringenin — clinical evidence
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Cross-database citation index for Naringenin as it relates to "clinical evidence".
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