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evidence · mechanism · dose
Supplements/Compound

Naringenin

Grapefruit flavonoid for metabolic health.

Overview

Grapefruit flavonoid for metabolic health.

Natural sources
    Common forms

      Mechanism of action

      Activates PPAR-α and inhibits HMG-CoA reductase.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers cholesterol (preclinical)

        Moderate evidence

        Potential side effects

        Common
        • · CYP3A4 inhibition
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            200–500 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Naringenin
            Amazon
            Wide selection · fast shipping
            Compound
            Naringenin
            iHerb
            Global delivery · curated brands
            Compound
            Naringenin
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalDiabetes · 2009

            Naringenin and metabolic syndrome

            Mulvihill EE, et al.

            LDLR-/- mice

            Key findings

            Prevented dyslipidemia and atherosclerosis.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Naringenin — Lowers cholesterol

            Live PubMed search

            Live results for "Naringenin Lowers cholesterol" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Naringenin and "Lowers cholesterol". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Naringenin — randomized controlled trial

            Live PubMed search

            Live results for "Naringenin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Naringenin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Naringenin — meta-analysis

            Live PubMed search

            Live results for "Naringenin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Naringenin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Naringenin — pharmacokinetics

            Live PubMed search

            Live results for "Naringenin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Naringenin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Naringenin — safety adverse events

            Live PubMed search

            Live results for "Naringenin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Naringenin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Naringenin — dose response

            Live PubMed search

            Live results for "Naringenin dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Naringenin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Naringenin — clinical evidence

            Live Scholar search

            Cross-database citation index for Naringenin as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.