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evidence · mechanism · dose
Supplements/Mineral

Magnesium Glycinate (Pre-Stimulant Use)

Pre-loaded magnesium glycinate reduces jaw clenching and post-use muscle tension during stimulant/MDMA use.

Pre-Drug Use SupportPost-Drug Use Recovery

Overview

Harm-reduction context: stimulants and MDMA cause significant bruxism (jaw clenching) and serotonergic muscle tension. Magnesium glycinate reduces these markedly.

Natural sources
    Common forms

      Mechanism of action

      Calcium-channel modulation and NMDA antagonism reduce neuromuscular hyperexcitability.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces MDMA-related bruxism (well-documented harm-reduction observation)

        Limited evidence

        Potential side effects

        Common
        • · Drowsiness
        • · Loose stools at high dose
        Rare
          Serious

            Drug interactions

            Quinolone/tetracycline antibiotics
            Chelates antibiotics.
            moderate

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Other notes
            • ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300–500 mg elemental, dosed 1–2h before and again 3–4h after
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalNeuron · 2010

            Magnesium and NMDA receptor modulation

            Slutsky I, et al.

            Animal study of magnesium on NMDA-receptor activity.

            Key findings

            Elevated brain Mg2+ improves synaptic plasticity and reduces excitotoxicity.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Glycinate (Pre-Stimulant Use) — Reduces MDMA-related bruxism

            Live PubMed search

            Live results for "Magnesium Glycinate (Pre-Stimulant Use) Reduces MDMA-related bruxism" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Glycinate (Pre-Stimulant Use) and "Reduces MDMA-related bruxism". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Glycinate (Pre-Stimulant Use) — randomized controlled trial

            Live PubMed search

            Live results for "Magnesium Glycinate (Pre-Stimulant Use) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Glycinate (Pre-Stimulant Use) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Glycinate (Pre-Stimulant Use) — meta-analysis

            Live PubMed search

            Live results for "Magnesium Glycinate (Pre-Stimulant Use) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Glycinate (Pre-Stimulant Use) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Glycinate (Pre-Stimulant Use) — pharmacokinetics

            Live PubMed search

            Live results for "Magnesium Glycinate (Pre-Stimulant Use) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Glycinate (Pre-Stimulant Use) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Glycinate (Pre-Stimulant Use) — safety adverse events

            Live PubMed search

            Live results for "Magnesium Glycinate (Pre-Stimulant Use) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Glycinate (Pre-Stimulant Use) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Magnesium Glycinate (Pre-Stimulant Use) — dose response

            Live PubMed search

            Live results for "Magnesium Glycinate (Pre-Stimulant Use) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Magnesium Glycinate (Pre-Stimulant Use) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Magnesium Glycinate (Pre-Stimulant Use) — clinical evidence

            Live Scholar search

            Cross-database citation index for Magnesium Glycinate (Pre-Stimulant Use) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.