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evidence · mechanism · dose
Supplements/Compound

Lactobacillus plantarum 299v

Single-strain probiotic with the strongest IBS evidence.

Overview

Single-strain probiotic with the strongest IBS evidence.

Natural sources
    Common forms

      Forms & variants of Multi-Strain Probiotic

      Different chemical forms of Multi-Strain Probiotic behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Multi-Strain Probiotic

      Live bacterial supplement — strain-specific effects on digestion, immunity, and mood.

      Mechanism of action

      Adheres to mannose receptors on enterocytes; produces short-chain fatty acids.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces IBS pain and bloating

        Strong evidence

        Potential side effects

        Common
        • · Initial bloating
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            10 billion CFU
            With food?
            With meals

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Lactobacillu…
            Amazon
            Wide selection · fast shipping
            Compound
            Lactobacillu…
            iHerb
            Global delivery · curated brands
            Compound
            Lactobacillu…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTWorld J Gastroenterol · 2012

            L. plantarum 299v in IBS

            Ducrotté P, et al.

            4-week DB-RCT in 214 IBS patients.

            Key findings

            Significantly reduced abdominal pain and bloating vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lactobacillus plantarum 299v — Reduces IBS pain and bloating

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            Live results for "Lactobacillus plantarum 299v Reduces IBS pain and bloating" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lactobacillus plantarum 299v and "Reduces IBS pain and bloating". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lactobacillus plantarum 299v — randomized controlled trial

            Live PubMed search

            Live results for "Lactobacillus plantarum 299v randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lactobacillus plantarum 299v and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lactobacillus plantarum 299v — meta-analysis

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            Live results for "Lactobacillus plantarum 299v meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Lactobacillus plantarum 299v and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lactobacillus plantarum 299v — pharmacokinetics

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            Live results for "Lactobacillus plantarum 299v pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lactobacillus plantarum 299v — safety adverse events

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            Live results for "Lactobacillus plantarum 299v safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Lactobacillus plantarum 299v — dose response

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            Live results for "Lactobacillus plantarum 299v dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Lactobacillus plantarum 299v — clinical evidence

            Live Scholar search

            Cross-database citation index for Lactobacillus plantarum 299v as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.