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evidence · mechanism · dose
Supplements/Amino Acid

L-Isoleucine

BCAA for glucose uptake.

Overview

BCAA for glucose uptake.

Natural sources
    Common forms

      Mechanism of action

      Stimulates glucose uptake into muscle.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Glucose disposal

        Moderate evidence

        Potential side effects

        Common
        • · Well tolerated
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            2–5 g

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Amino Acid
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalJ Nutr · 2007

            Isoleucine and glucose

            Doi M, et al.

            Rat skeletal muscle

            Key findings

            Stimulated glucose uptake.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Isoleucine — Glucose disposal

            Live PubMed search

            Live results for "L-Isoleucine Glucose disposal" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Isoleucine and "Glucose disposal". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Isoleucine — randomized controlled trial

            Live PubMed search

            Live results for "L-Isoleucine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Isoleucine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Isoleucine — meta-analysis

            Live PubMed search

            Live results for "L-Isoleucine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Isoleucine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Isoleucine — pharmacokinetics

            Live PubMed search

            Live results for "L-Isoleucine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Isoleucine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Isoleucine — safety adverse events

            Live PubMed search

            Live results for "L-Isoleucine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Isoleucine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Isoleucine — dose response

            Live PubMed search

            Live results for "L-Isoleucine dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Isoleucine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: L-Isoleucine — clinical evidence

            Live Scholar search

            Cross-database citation index for L-Isoleucine as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.