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Iberogast (STW-5)

Nine-herb European tincture for functional dyspepsia and IBS.

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Overview

Nine-herb European tincture for functional dyspepsia and IBS.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Region-specific modulation of GI smooth muscle tone and visceral hypersensitivity.

Pathways
  • · Region-specific modulation of GI smooth muscle tone
  • · visceral hypersensitivity

Effects on the body

Supports
dyspepsia and IBS symptoms

Organ system effects

Evidence-based benefits

Improves dyspepsia and IBS symptoms

Strong evidence

Potential side effects

Common
  • · Mild GI symptoms
Rare
  • · Idiosyncratic hepatotoxicity
Serious

    Drug interactions

    Prescription medications (general)
    Always disclose Iberogast (STW-5) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
    minor

    Safety & non-supplemental interactions

    Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

    Avoid if you are
    • ·Pregnant or breastfeeding (insufficient safety data)
    • ·Children under 18 (unless directed by a clinician)

    Supplement interactions

    Pairs well with
    • A high-quality multivitamin
      Covers micronutrient cofactors that support most supplement pathways.
    • Omega-3 (EPA/DHA)
      Foundational anti-inflammatory support that complements most regimens.
    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    20 drops tid
    Best form
    Most evidence is based on the standardized extract capsule form.
    Timing
    Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
    With food?
    With meals

    Where to buy

    Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Scientific evidence8Show studies
    RCTAliment Pharmacol Ther · 2004

    STW-5 vs placebo in functional dyspepsia

    Madisch A, et al.

    8-week DB-RCT in 315 patients.

    Key findings

    Significantly improved GI symptom score vs placebo.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iberogast (STW-5) — Improves dyspepsia and IBS symptoms

    Live PubMed search

    Live results for "Iberogast (STW-5) Improves dyspepsia and IBS symptoms" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iberogast (STW-5) and "Improves dyspepsia and IBS symptoms". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iberogast (STW-5) — randomized controlled trial

    Live PubMed search

    Live results for "Iberogast (STW-5) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iberogast (STW-5) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iberogast (STW-5) — meta-analysis

    Live PubMed search

    Live results for "Iberogast (STW-5) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iberogast (STW-5) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iberogast (STW-5) — pharmacokinetics

    Live PubMed search

    Live results for "Iberogast (STW-5) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iberogast (STW-5) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iberogast (STW-5) — safety adverse events

    Live PubMed search

    Live results for "Iberogast (STW-5) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iberogast (STW-5) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Iberogast (STW-5) — dose response

    Live PubMed search

    Live results for "Iberogast (STW-5) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Iberogast (STW-5) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Iberogast (STW-5) — clinical evidence

    Live Scholar search

    Cross-database citation index for Iberogast (STW-5) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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