L-Glutamine (Gut)
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L-Glutamine (Gut). Primary fuel for enterocytes; supports tight junctions.
How it works. Enterocyte energy substrate; upregulates claudin-1 and occludin expression.
What the research supports. 1 graded claims. Strongest: Reduces IBS symptoms post-infection (moderate).
How much to take. Typical dose: 5 g tid.
Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.
Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).
Common forms. Available as Free-form crystalline powder, Capsules or tablets, Pre-mixed recovery or hydration beverages, Time-release formulations.
Key studies. 8 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried L-Glutamine (Gut). Anecdotes are not medical advice.
L-Glutamine (Gut). Primary fuel for enterocytes; supports tight junctions.
What it is
Primary fuel for enterocytes; supports tight junctions.
Food sources
How it works
Enterocyte energy substrate; upregulates claudin-1 and occludin expression.
Pathways
- Enterocyte energy substrate
- upregulates claudin-1
- occludin expression
Effects
- ↓IBS symptoms post-infection decreases
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- GI upset at high dose
Medication interactions
Always disclose L-Glutamine (Gut) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
Common forms
- Free-form crystalline powder
- Capsules or tablets
- Pre-mixed recovery or hydration beverages
- Time-release formulations
Key studies
8 studies cited in total.
Opens current human and preclinical literature matching L-Glutamine (Gut) and "Reduces IBS symptoms post-infection". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching L-Glutamine (Gut) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching L-Glutamine (Gut) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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