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evidence · mechanism · dose
Supplements/Amino Acid

L-Glutamine (Gut)

Primary fuel for enterocytes; supports tight junctions.

Overview

Primary fuel for enterocytes; supports tight junctions.

Natural sources
    Common forms

      Forms & variants of L-Glutamine

      Different chemical forms of L-Glutamine behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      L-Glutamine

      Most abundant amino acid; primary fuel for enterocytes and immune cells.

      Mechanism of action

      Enterocyte energy substrate; upregulates claudin-1 and occludin expression.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces IBS symptoms post-infection

        Moderate evidence

        Potential side effects

        Common
        • · GI upset at high dose
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            5 g tid
            With food?
            Between meals

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Amino Acid
            L-Glutamine …
            Amazon
            Wide selection · fast shipping
            Amino Acid
            L-Glutamine …
            iHerb
            Global delivery · curated brands
            Amino Acid
            L-Glutamine …
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTGut · 2019

            Glutamine in post-infectious IBS

            Zhou Q, et al.

            8-week DB-RCT in 106 PI-IBS patients.

            Key findings

            5 g tid significantly improved IBS severity score vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Glutamine (Gut) — Reduces IBS symptoms post-infection

            Live PubMed search

            Live results for "L-Glutamine (Gut) Reduces IBS symptoms post-infection" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Glutamine (Gut) and "Reduces IBS symptoms post-infection". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Glutamine (Gut) — randomized controlled trial

            Live PubMed search

            Live results for "L-Glutamine (Gut) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Glutamine (Gut) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Glutamine (Gut) — meta-analysis

            Live PubMed search

            Live results for "L-Glutamine (Gut) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Glutamine (Gut) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Glutamine (Gut) — pharmacokinetics

            Live PubMed search

            Live results for "L-Glutamine (Gut) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Glutamine (Gut) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Glutamine (Gut) — safety adverse events

            Live PubMed search

            Live results for "L-Glutamine (Gut) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Glutamine (Gut) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Glutamine (Gut) — dose response

            Live PubMed search

            Live results for "L-Glutamine (Gut) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Glutamine (Gut) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: L-Glutamine (Gut) — clinical evidence

            Live Scholar search

            Cross-database citation index for L-Glutamine (Gut) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.