SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

FODZYME (α-galactosidase + lactase)

Enzyme blend that breaks down FODMAPs at the meal level.

Buy
Quick picks · code supplementsch-20 auto-appliedSee all →
Third-party testedThird-party testedAmazon →CapsulesCapsulesAmazon →PowderPowderAmazon →Best sellersBest sellersAmazon →

Overview

Enzyme blend that breaks down FODMAPs at the meal level.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Cleaves fructans, galactans, and lactose before fermentation in the colon.

Pathways
  • · Cleaves fructans, galactans
  • · and lactose before fermentation in the colon

Effects on the body

Decreases
FODMAP-induced symptoms

Organ system effects

Evidence-based benefits

Reduces FODMAP-induced symptoms

Limited evidence

Potential side effects

Common
  • · FODZYME (α-galactosidase + lactase) is generally well-tolerated at evidence-based doses
  • · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
  • · Headache or transient fatigue reported by a small fraction of users
Rare
  • · Allergic or hypersensitivity reaction (rash, itching, swelling)
  • · Sleep disturbance if taken late in the day
Serious
  • · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing

Drug interactions

Prescription medications (general)
Always disclose FODZYME (α-galactosidase + lactase) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
minor

Supplement interactions

Pairs well with
  • A high-quality multivitamin
    Covers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)
    Foundational anti-inflammatory support that complements most regimens.
Avoid combining with

No specific avoidances listed.

Dosing & bioavailability

Typical dose
1 scoop per high-FODMAP meal
Best form
Most evidence is based on the capsule or softgel form.
Timing
Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
With food?
With meals

Where to buy

Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

Buy on AmazonCode supplementsch-20 auto-applied
Suggested products
Third-party testedThird-party testedIndependently verified FODZYME (α-galactosidase + lactase) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.FODZYME (α-galactosidase + lactase) third party tested NSFCapsulesCapsulesPre-measured FODZYME (α-galactosidase + lactase) capsules — easiest for travel and consistent daily dosing without scoops or scales.FODZYME (α-galactosidase + lactase) capsulesPowderPowderBulk unflavored FODZYME (α-galactosidase + lactase) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.FODZYME (α-galactosidase + lactase) powder unflavoredBest sellersBest sellersMost-purchased FODZYME (α-galactosidase + lactase) products on Amazon — a quick way to see what's reviewed widely before you commit.FODZYME (α-galactosidase + lactase) best seller
Scientific evidence8Show studies
RCTAliment Pharmacol Ther · 2007

α-galactosidase in IBS with gas

Di Stefano M, et al.

Crossover RCT in 8 IBS patients.

Key findings

Reduced flatus and pain after legume meals.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: FODZYME (α-galactosidase + lactase) — Reduces FODMAP-induced symptoms

Live PubMed search

Live results for "FODZYME (α-galactosidase + lactase) Reduces FODMAP-induced symptoms" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching FODZYME (α-galactosidase + lactase) and "Reduces FODMAP-induced symptoms". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: FODZYME (α-galactosidase + lactase) — randomized controlled trial

Live PubMed search

Live results for "FODZYME (α-galactosidase + lactase) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching FODZYME (α-galactosidase + lactase) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: FODZYME (α-galactosidase + lactase) — meta-analysis

Live PubMed search

Live results for "FODZYME (α-galactosidase + lactase) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching FODZYME (α-galactosidase + lactase) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: FODZYME (α-galactosidase + lactase) — pharmacokinetics

Live PubMed search

Live results for "FODZYME (α-galactosidase + lactase) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching FODZYME (α-galactosidase + lactase) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: FODZYME (α-galactosidase + lactase) — safety adverse events

Live PubMed search

Live results for "FODZYME (α-galactosidase + lactase) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching FODZYME (α-galactosidase + lactase) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: FODZYME (α-galactosidase + lactase) — dose response

Live PubMed search

Live results for "FODZYME (α-galactosidase + lactase) dose response" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching FODZYME (α-galactosidase + lactase) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewGoogle Scholar · 1970

Google Scholar: FODZYME (α-galactosidase + lactase) — clinical evidence

Live Scholar search

Cross-database citation index for FODZYME (α-galactosidase + lactase) as it relates to "clinical evidence".

Key findings

Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

Open study
Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

Community discussion

(0 threads)

Share your experience or read what others have tried. Anecdotes are not medical advice.

Sign in or create a free account to post or reply.
Loading discussion…