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Compound

Eggshell Membrane

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Eggshell Membrane. NEM hydrolyzed eggshell for joints.

How it works. Provides collagen, glycosaminoglycans, and hyaluronic acid.

What the research supports. 1 graded claims. Strongest: Reduces joint pain (moderate).

How much to take. Typical dose: 500 mg.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Eggshell Membrane. Anecdotes are not medical advice.

Eggshell Membrane. NEM hydrolyzed eggshell for joints.

No single structure

What it is

NEM hydrolyzed eggshell for joints.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

How it works

Provides collagen, glycosaminoglycans, and hyaluronic acid.

Pathways

  • Provides collagen, glycosaminoglycans
  • and hyaluronic acid

Effects

  • ↓joint pain decreases

What the research supports

Reduces joint painmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
500 mg
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Egg allergy

Medication interactions

Prescription medications (general)minor

Always disclose Eggshell Membrane use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Eggshell Membrane — Reduces joint pain ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Eggshell Membrane and "Reduces joint pain". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Eggshell Membrane — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Eggshell Membrane and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Eggshell Membrane — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Eggshell Membrane and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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