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evidence · mechanism · dose
Supplements/Compound

Eggshell Membrane

NEM hydrolyzed eggshell for joints.

Overview

NEM hydrolyzed eggshell for joints.

Natural sources
    Common forms

      Mechanism of action

      Provides collagen, glycosaminoglycans, and hyaluronic acid.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces joint pain

        Moderate evidence

        Potential side effects

        Common
        • · Egg allergy
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Eggshell Mem…
            Amazon
            Wide selection · fast shipping
            Compound
            Eggshell Mem…
            iHerb
            Global delivery · curated brands
            Compound
            Eggshell Mem…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTClin Interv Aging · 2009

            NEM in OA

            Ruff KJ, et al.

            67 OA patients

            Key findings

            Reduced pain and stiffness at 30 days.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Eggshell Membrane — Reduces joint pain

            Live PubMed search

            Live results for "Eggshell Membrane Reduces joint pain" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Eggshell Membrane and "Reduces joint pain". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Eggshell Membrane — randomized controlled trial

            Live PubMed search

            Live results for "Eggshell Membrane randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Eggshell Membrane and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Eggshell Membrane — meta-analysis

            Live PubMed search

            Live results for "Eggshell Membrane meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Eggshell Membrane and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Eggshell Membrane — pharmacokinetics

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Eggshell Membrane — safety adverse events

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Eggshell Membrane — dose response

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            Key findings

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            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Eggshell Membrane — clinical evidence

            Live Scholar search

            Cross-database citation index for Eggshell Membrane as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.