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evidence · mechanism · dose
Supplements/Compound

Dihydroberberine

Bioavailable berberine derivative.

Overview

Bioavailable berberine derivative.

Natural sources
    Common forms

      Mechanism of action

      Reduced form converted back to berberine with higher absorption.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Higher bioavailability than berberine

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            200 mg BID

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Dihydroberbe…
            Amazon
            Wide selection · fast shipping
            Compound
            Dihydroberbe…
            iHerb
            Global delivery · curated brands
            Compound
            Dihydroberbe…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalDiabetes · 2008

            Dihydroberberine bioavailability

            Turner N, et al.

            High-fat diet rats

            Key findings

            Five times more bioavailable than berberine.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydroberberine — Higher bioavailability than berberine

            Live PubMed search

            Live results for "Dihydroberberine Higher bioavailability than berberine" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydroberberine and "Higher bioavailability than berberine". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydroberberine — randomized controlled trial

            Live PubMed search

            Live results for "Dihydroberberine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydroberberine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydroberberine — meta-analysis

            Live PubMed search

            Live results for "Dihydroberberine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydroberberine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydroberberine — pharmacokinetics

            Live PubMed search

            Live results for "Dihydroberberine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydroberberine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydroberberine — safety adverse events

            Live PubMed search

            Live results for "Dihydroberberine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydroberberine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydroberberine — dose response

            Live PubMed search

            Live results for "Dihydroberberine dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydroberberine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Dihydroberberine — clinical evidence

            Live Scholar search

            Cross-database citation index for Dihydroberberine as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.