DGL (Deglycyrrhizinated Licorice)
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DGL (Deglycyrrhizinated Licorice). Licorice with glycyrrhizin removed; soothes GI mucosa without BP effect.
How it works. Increases mucin secretion and epidermal growth factor in gastric mucosa.
What the research supports. 1 graded claims. Strongest: Heals gastric ulcers and reduces NSAID gastritis (moderate).
How much to take. Typical dose: 380–760 mg chewed before meals.
Side effects and interactions. 1 medication interaction listed. Serious: Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing.
Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).
Common forms. Available as Chewable DGL tablets.
Key studies. 8 studies cited. The strongest are listed with links to PubMed.
Community. Experiences from people who have tried DGL (Deglycyrrhizinated Licorice). Anecdotes are not medical advice.
DGL (Deglycyrrhizinated Licorice). Licorice with glycyrrhizin removed; soothes GI mucosa without BP effect.
What it is
Licorice with glycyrrhizin removed; soothes GI mucosa without BP effect.
Also called
Food sources
Goals
How it works
Increases mucin secretion and epidermal growth factor in gastric mucosa.
Pathways
- Mucin secretion ↑
Effects
- +Gastric mucosal protection supports
What the research supports
Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.
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Side effects & interactions
Common side effects
- DGL (Deglycyrrhizinated Licorice) is generally well-tolerated at evidence-based doses
- Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- Headache or transient fatigue reported by a small fraction of users
Serious
- Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Medication interactions
Always disclose DGL (Deglycyrrhizinated Licorice) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
Check any supplement–medication combination with your pharmacist before starting.
Combines with
Pairs well
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
Common forms
- Chewable DGL tablets
Key studies
8 studies cited in total.
Opens current human and preclinical literature matching DGL (Deglycyrrhizinated Licorice) and "Heals gastric ulcers and reduces NSAID gastritis". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching DGL (Deglycyrrhizinated Licorice) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
Opens current human and preclinical literature matching DGL (Deglycyrrhizinated Licorice) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
Discussion
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