Overview
Harpagophytum procumbens for joint pain.
- Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
- Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
- Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
- Standardized extract capsule
- Liquid tincture (alcohol or glycerin)
- Powdered whole herb
- Traditional decoction or tea
Mechanism of action
Harpagosides inhibit COX-2 and inflammatory cytokines.
- · Harpagosides inhibit COX-2
- · inflammatory cytokines
Effects on the body
Organ system effects
Evidence-based benefits
Reduces OA pain
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Devil's claw for low back pain
Gagnier JJ, et al.
12 RCTs
Effective for non-specific low back pain.
PubMed: Devil's Claw — Reduces OA pain
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