Overview
15 g hydrolyzed collagen + 50 mg vit C taken 60 min pre-rehab — Shaw 2017 protocol.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Spikes plasma glycine/proline + vit C cofactor; loaded tissue uses substrate for collagen synthesis.
- · Spikes plasma glycine/proline + vit C cofactor
- · loaded tissue uses substrate for collagen synthesis
Effects on the body
Organ system effects
Evidence-based benefits
Doubles collagen synthesis pre-rehab (Shaw 2017)
Moderate evidencePotential side effects
- · Collagen + Vitamin C (Tendon Protocol) is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Collagen + Vitamin C (Tendon Protocol) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Collagen + Vitamin C (Tendon Protocol) third party tested NSF
CapsulesPre-measured Collagen + Vitamin C (Tendon Protocol) capsules — easiest for travel and consistent daily dosing without scoops or scales.Collagen + Vitamin C (Tendon Protocol) capsules
PowderBulk unflavored Collagen + Vitamin C (Tendon Protocol) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Collagen + Vitamin C (Tendon Protocol) powder unflavored
Best sellersMost-purchased Collagen + Vitamin C (Tendon Protocol) products on Amazon — a quick way to see what's reviewed widely before you commit.Collagen + Vitamin C (Tendon Protocol) best sellerScientific evidence8Show studiesHide studies
Vitamin C–enriched gelatin supplementation before activity augments collagen synthesis
Shaw G, et al.
Crossover trial of 15 g gelatin + vitamin C before training.
Doubled circulating PINP, a marker of collagen synthesis.
PubMed: Collagen + Vitamin C (Tendon Protocol) — Doubles collagen synthesis pre-rehab
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