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evidence · mechanism · dose
Supplements/Compound

Collagen + Vitamin C (Tendon Protocol)

15 g hydrolyzed collagen + 50 mg vit C taken 60 min pre-rehab — Shaw 2017 protocol.

Tendon HealthLigament HealthJoint PainAthletic Recovery

Overview

15 g hydrolyzed collagen + 50 mg vit C taken 60 min pre-rehab — Shaw 2017 protocol.

Natural sources
    Common forms

      Mechanism of action

      Spikes plasma glycine/proline + vit C cofactor; loaded tissue uses substrate for collagen synthesis.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Doubles collagen synthesis pre-rehab (Shaw 2017)

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              15 g collagen + 50 mg vit C 60 min pre-loading
              With food?
              Pre-rehab

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTAm J Clin Nutr · 2017

              Vitamin C–enriched gelatin supplementation before activity augments collagen synthesis

              Shaw G, et al.

              Crossover trial of 15 g gelatin + vitamin C before training.

              Key findings

              Doubled circulating PINP, a marker of collagen synthesis.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Collagen + Vitamin C (Tendon Protocol) — Doubles collagen synthesis pre-rehab

              Live PubMed search

              Live results for "Collagen + Vitamin C (Tendon Protocol) Doubles collagen synthesis pre-rehab" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Collagen + Vitamin C (Tendon Protocol) and "Doubles collagen synthesis pre-rehab". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Collagen + Vitamin C (Tendon Protocol) — randomized controlled trial

              Live PubMed search

              Live results for "Collagen + Vitamin C (Tendon Protocol) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Collagen + Vitamin C (Tendon Protocol) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Collagen + Vitamin C (Tendon Protocol) — meta-analysis

              Live PubMed search

              Live results for "Collagen + Vitamin C (Tendon Protocol) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Collagen + Vitamin C (Tendon Protocol) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Collagen + Vitamin C (Tendon Protocol) — pharmacokinetics

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              Live results for "Collagen + Vitamin C (Tendon Protocol) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Collagen + Vitamin C (Tendon Protocol) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Collagen + Vitamin C (Tendon Protocol) — safety adverse events

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              Live results for "Collagen + Vitamin C (Tendon Protocol) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Collagen + Vitamin C (Tendon Protocol) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Collagen + Vitamin C (Tendon Protocol) — dose response

              Live PubMed search

              Live results for "Collagen + Vitamin C (Tendon Protocol) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Collagen + Vitamin C (Tendon Protocol) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Collagen + Vitamin C (Tendon Protocol) — clinical evidence

              Live Scholar search

              Cross-database citation index for Collagen + Vitamin C (Tendon Protocol) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.