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evidence · mechanism · dose
Supplements/Mineral

Chromium Picolinate

Trivalent chromium for glucose handling.

Overview

Trivalent chromium for glucose handling.

Natural sources
    Common forms

      Mechanism of action

      Potentiates insulin via chromodulin.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Modest HbA1c reduction

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            200–1000 mcg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Mineral
            Chromium Pic…
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            Chromium Pic…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Meta-analysisJ Clin Pharm Ther · 2014

            Chromium meta-analysis

            Suksomboon N, et al.

            25 RCTs

            Key findings

            Reduced fasting glucose and HbA1c.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Chromium Picolinate — Modest HbA1c reduction

            Live PubMed search

            Live results for "Chromium Picolinate Modest HbA1c reduction" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Chromium Picolinate and "Modest HbA1c reduction". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Chromium Picolinate — randomized controlled trial

            Live PubMed search

            Live results for "Chromium Picolinate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Chromium Picolinate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Chromium Picolinate — meta-analysis

            Live PubMed search

            Live results for "Chromium Picolinate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Chromium Picolinate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Chromium Picolinate — pharmacokinetics

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            Live results for "Chromium Picolinate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Chromium Picolinate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Chromium Picolinate — safety adverse events

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Chromium Picolinate — dose response

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            Live results for "Chromium Picolinate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Chromium Picolinate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Chromium Picolinate — clinical evidence

            Live Scholar search

            Cross-database citation index for Chromium Picolinate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.