Supplement Scholar
Compound

Cetyl Myristoleate (CMO)

Buy on Amazon ↗

Affiliate link: we may earn a commission at no extra cost to you. Disclosures

Cetyl Myristoleate (CMO). Fatty acid for joint health.

How it works. Lubricant and anti-inflammatory.

What the research supports. 1 graded claims. Strongest: Reduces arthritis pain (moderate).

How much to take. Typical dose: 540 mg/d.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with A high-quality multivitamin, Omega-3 (EPA/DHA).

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Cetyl Myristoleate (CMO). Anecdotes are not medical advice.

Cetyl Myristoleate (CMO). Fatty acid for joint health.

Molecular structureC30H58O2 · 450.8 g/mol

What it is

Fatty acid for joint health.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

How it works

Lubricant and anti-inflammatory.

Pathways

  • Lubricant
  • anti-inflammatory

Effects

  • ↓arthritis pain decreases

What the research supports

Reduces arthritis painmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
540 mg/d
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
Shop Cetyl Myristoleate (CMO) on Amazon ↗

As an Amazon Associate I earn from qualifying purchases. Look for USP, NSF or Informed Sport seals before you buy.

Side effects & interactions

Common side effects

  • GI upset

Medication interactions

Prescription medications (general)minor

Always disclose Cetyl Myristoleate (CMO) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Cetyl Myristoleate (CMO) — Reduces arthritis pain ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Cetyl Myristoleate (CMO) and "Reduces arthritis pain". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Cetyl Myristoleate (CMO) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Cetyl Myristoleate (CMO) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Cetyl Myristoleate (CMO) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Cetyl Myristoleate (CMO) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

Loading discussion…