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evidence · mechanism · dose
Supplements/Herb

Cayenne (Capsaicin)

Capsicum for topical pain and metabolic support.

Overview

Capsicum for topical pain and metabolic support.

Natural sources
    Common forms

      Mechanism of action

      TRPV1 desensitization depletes substance P.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces neuropathic pain

        Moderate evidence

        Potential side effects

        Common
        • · Burning
        • · Skin redness
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            0.025–0.075% topical

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
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            iHerb
            Global delivery · curated brands
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Meta-analysisCochrane · 2017

            Capsaicin for neuropathic pain

            Derry S, et al.

            7 trials

            Key findings

            High-dose capsaicin patches effective for postherpetic neuralgia.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cayenne (Capsaicin) — Reduces neuropathic pain

            Live PubMed search

            Live results for "Cayenne (Capsaicin) Reduces neuropathic pain" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cayenne (Capsaicin) and "Reduces neuropathic pain". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cayenne (Capsaicin) — randomized controlled trial

            Live PubMed search

            Live results for "Cayenne (Capsaicin) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cayenne (Capsaicin) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cayenne (Capsaicin) — meta-analysis

            Live PubMed search

            Live results for "Cayenne (Capsaicin) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cayenne (Capsaicin) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cayenne (Capsaicin) — pharmacokinetics

            Live PubMed search

            Live results for "Cayenne (Capsaicin) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cayenne (Capsaicin) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cayenne (Capsaicin) — safety adverse events

            Live PubMed search

            Live results for "Cayenne (Capsaicin) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cayenne (Capsaicin) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cayenne (Capsaicin) — dose response

            Live PubMed search

            Live results for "Cayenne (Capsaicin) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cayenne (Capsaicin) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Cayenne (Capsaicin) — clinical evidence

            Live Scholar search

            Cross-database citation index for Cayenne (Capsaicin) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.